MUC2 (MRQ-18)

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DIAGNOSTICS F. Hoffmann-La Roche Ltd

MUC2 (MRQ-18)

MUC2 (MRQ-18), colon, 200x
Catalog Number:760-4388
Ordering Code:05463556001
Quantity:50 tests
Controls:Colon, Colon Adenocarcinoma
Clone Name:MRQ-18
Regulatory Status:IVD

The heterogeneous pattern of mucin expression, including the expression of the intestinal mucin MUC2, may provide new insights into the differentiation pathways of gastric carcinoma. The pattern of mucin expression may also be used as a clue to bring new insights into the biological behaviour of distinct clinicopathological entities related to the localisation of gastric carcinoma, namely proximal and distal gastric carcinomas. Pinto-de-Sousa et al. have shown in a comprehensive study of gastric carcinomas evaluated for expression of several mucins (MUC1, MUC2, MUC5AC and MUC6) that: (1) mucin expression is associated with tumour type (MUC5AC with diffuse and infiltrative carcinomas and MUC2 with mucinous carcinomas) but not with the clinico-biological behaviour of the tumours; and (2) mucin expression is associated with tumour location (MUC5AC with antrum carcinomas and MUC2 with cardia carcinomas), indirectly reflecting differences in tumour differentiation according to tumour location.