ACTH (polyclonal)

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DIAGNOSTICS F. Hoffmann-La Roche Ltd

ACTH (polyclonal)

ACTH (polyclonal), pituitary, 100x
Catalog Number:760-2708
Ordering Code:05268176001
Quantity:50 tests
Controls:Normal Pituitary
Clone Name:Polyclonal
Species:Rabbit
Localization:Cytoplasmic
Regulatory Status:IVD


ACTH is synthesized from pre-pro-opiomelanocortin (pre-POMC). The removal of the single peptide during translation produces the 267 amino acid polypeptide POMC, which undergoes a series of post-translational modifications such as phosphorylation and glycosylation before it is proteolytically cleaved by endopeptidases to yield various polypeptide fragments with varying physiological activity. These fragments include ACTH, ß-lipotropin, ?-lipotropin, Melanocyte Stimulating Hormone (MSH), and ß-endorphin. POMC, ACTH, and ß-lipotropin are secreted from corticotropes in the anterior lobe (or adenohypophysis) of the pituitary gland in response to the hormone corticotropin-releasing hormone (CRH) released by the hypothalamus. ACTH is also produced by cells of immune system (T-cells, B-cells, and macrophages) in response to stimuli associated with stress. Anti-ACTH is a useful marker in classification of pituitary tumors and the study of pituitary disease. It reacts with ACTH-producing cells (corticotrophs). It also may react with other tumors (e.g. some small cell carcinomas of the lung) causing paraneoplastic syndromes by secreting ACTH.


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