PD-1 (NAT105)

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DIAGNOSTICS F. Hoffmann-La Roche Ltd

PD-1 (NAT105) Mouse Monoclonal Antibody

PD-1 (NAT105), tonsil, 200x
Catalog Number:760-4895
Ordering Code:07099029001
Quantity:50 tests
Controls:Lymph Node, Tonsil
Isotypes:IgG1
Clone Name:NAT105
Species:Mouse
Localization:Cytoplasmic
Regulatory Status:IVD


Programmed death-1 (PD-1) is a member of the CD28 family of receptors that includes CD28, cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4), inducible costimulator (ICOS), and B- and T-lymphocyte attenuator. These receptors play a role in the cellular immune response. For example, CD28 serves as a costimulatory receptor that enhances T-cell activation, whereas CTLA-4 serves as an inhibitor of T-cell activation. PD-1 also has an inhibitory function on T cells and B cells, and is important in peripheral tolerance. There are at least 2 ligands for PD-1, PD-L1, and PD-L2, which are expressed on a range of cells.


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