Perforin (MRQ-23)

Skip to Content

Skip over Generic Navigation

  • Select your country:
DIAGNOSTICS F. Hoffmann-La Roche Ltd

Perforin (MRQ-23)

Perforin (MRQ-23), lymphoma, 300x
Catalog Number:760-4394
Ordering Code:05463637001
Quantity:50 tests
Controls:Lymph Node, Tonsil
Clone Name:MRQ-23
Localization:Perinuclear Cytoplasmic
Regulatory Status:ASR

Perforin is a pore-forming protein that leads to osmotic lysis of the target cells and subsequently enables granzymes to enter the target cells and activate apoptosis, the cell death program. The expression of perforin is upregulated in activated CD8+ T cells, but in NK cells the expression is constitutively very high and stable. Perforin expression can also be stimulated in some activated CD4+ T cells. CD8+ T cells and NK cells use both the perforin/granzyme and the Fas /FasL pathways, while CD4+ T cells preferentially use the Fas /FasL pathway.

Health Care Provider Notice
This website is intended for healthcare professionals only.

The content on this website is intended for healthcare professionals only. Information intended for the general public can be found on Please confirm that you are a medical professional before accessing the content of this website.

Yes, I hereby certify that I am a healthcare professional. Continue
Third-Party Link Disclosure
Disclosure for Links to Third-Party Websites

You are now leaving the Roche website. The site you are about to visit is operated by third-parties. The link to this site neither makes nor implies any representation or warranty for any products or services offered on a third-party site and is intended only to enable convenient access to the third-party site and for no other purpose.