PGP 9.5 (polyclonal)

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DIAGNOSTICS F. Hoffmann-La Roche Ltd

PGP 9.5 Rabbit Polyclonal Antibody

PGP 9.5 Rabbit Polyclonal Antibody, colon, 150x
Catalog Number:760-4434
Ordering Code:05973953001
Quantity:50 tests
Controls:Bowel Wall (Interstitial Cells of Cajal), Nerve Tissue
Clone Name:Polyclonal
Regulatory Status:IVD

Protein gene product 9.5 (PGP 9.5), also known as ubiquitin carboxyl-terminal hydrolase-1 (UCH-L1), is a 27-kDa protein originally isolated from whole brain extracts (1). Although PGP9.5 expression in normal tissues was originally felt to be strictly confined to neurons and neuroendocrine cells (2), it has been subsequently documented in distal renal tubular epithelium, spermatogonia, Leydig cells, oocytes, melanocytes, prostatic secretory epithelium, ejaculatory duct cells, epididymis, mammary epithelial cells, Merkel cells, and dermal fibroblasts. LK Campbell et al demonstrated immunostaining of a plethora of different mesenchymal neoplasms with this antibody.