bcl-6 (GI191E/A8)

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DIAGNOSTICS F. Hoffmann-La Roche Ltd

bcl-6 (GI191E/A8)

bcl-6 (GI191E/A8), tonsil, 200x
Catalog Number:760-4241
Ordering Code:05269008001
Quantity:50 tests
Controls:Lymph Node, Tonsil
Isotypes:IgG1
Clone Name:GI191E/A8
Species:Mouse
Localization:Nuclear
Regulatory Status:IVD


Anti-bcl-6 is a transcriptional regulator gene which codes for a 706-amino-acid nuclear zinc finger protein. Antibodies to this protein stain the germinal center cells in lymphoid follicles, the follicular cells and interfollicular cells in follicular lymphoma, diffuse large B-cell lymphomas, and Burkitt's lymphoma, and the majority of the Reed-Sternberg cells in nodular lymphocyte predominant Hodgkin's Disease. In contrast, anti-bcl-6 rarely stains mantle cell lymphoma and MALT lymphoma. Anti-bcl-6 expression is seen in approximately 45% of CD30+ anaplastic large cell lymphomas but is consistently absent in other peripheral T-cell lymphomas. bcl-6 is protected by U.S. patents 6,174,997 and 6,783,94 (Cancer Genetics, Inc.)


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