VENTANA PD-L1 (SP142) Assay

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DIAGNOSTICS F. Hoffmann-La Roche Ltd

VENTANA PD-L1 (SP142) Assay

Positive UC tissue stained with PD-L1 (SP142) assay, 10x
Catalog Number:740-4859
Ordering Code:07709374001
Quantity:50 tests
Controls:Tonsil
Clone Name:SP142
Species:Rabbit
Localization:Membranous and/or Cytoplasmic Staining
Regulatory Status:IVD

VENTANA PD-L1 (SP142) Assay is a qualitative immunohistochemical assay using rabbit monoclonal anti-PD-L1 clone SP142 intended for use in the assessment of the PD-L1 protein in formalin-fixed, paraffin-embedded (FFPE) urothelial carcinoma and non-small cell lung cancer (NSCLC) tissue stained with OptiView DAB IHC Detection Kit and OptiView Amplification Kit on a VENTANA BenchMark ULTRA instrument. Determination of PD-L1 status is indication-specific, and evaluation is based on either the proportion of tumor area occupied by PD-L1 expressing tumor-infiltrating immune cells (% IC) of any intensity or the percentage of PD-L1 expressing tumor cells (% TC) of any intensity.

PD-L1 expression in ≥ 5% IC determined by VENTANA PD-L1 (SP142) Assay in urothelial carcinoma tissue is indicated as an aid in identifying urothelial carcinoma patients for treatment with TECENTRIQ® (atezolizumab).

PD-L1 expression in ≥ 50% TC or ≥ 10% IC determined by VENTANA PD-L1 (SP142) Assay in NSCLC tissue may be associated with enhanced overall survival from TECENTRIQ® (atezolizumab).

See the TECENTRIQ® product label for PD-L1 expression cutoff values guiding therapy in specific clinical circumstances.

This product is intended for in vitro diagnostic (IVD) use.


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