CD2 (MRQ-11)

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DIAGNOSTICS F. Hoffmann-La Roche Ltd

CD2 (MRQ-11)

CD2 (MRQ-11), tonsil, 200x
Catalog Number:760-4377
Ordering Code:05463467001
Quantity:50 tests
Controls:Lymph Node, Tonsil
Clone Name:MRQ-11
Localization:Cytoplasmic, Membranous
Regulatory Status:IVD

CD2 can be considered a pan-T cell antigen and is therefore useful for the identification of virtually all normal T lymphocytes. It is also very useful in the assessment of lymphoid malignancies as it is expressed in the majority of precursor and post-thymic lymphomas and leukemias and is not expressed by B neoplasms (Foon & Todd, 1986). As with other pan-T cell antigens, CD2 may be aberrantly deleted in some neoplastic T cell population, especially peripheral T cell lymphomas. Rarely slg+ B cell neoplasms have been described to form spontaneous E-rosettes but these reactions are not mediated via the CD2 receptor (Knowles, 1989).