Ep-CAM (Ber-EP4)

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DIAGNOSTICS F. Hoffmann-La Roche Ltd

Ep-CAM (Ber-EP4)

Ep-CAM (Ber-EP4), colon, 100x
Catalog Number:760-4383
Ordering Code:05435676001
Quantity:50 tests
Controls:Adenocarcinoma, Columnar Epithelium
Clone Name:Ber-EP4
Regulatory Status:IVD

Ep-CAM consists of two glycoproteins, 34 and 39 kDa, sometimes designated epithelial antigen, epithelial specific antigen, and epithelial glycoprotein. In paraffin sections, the protein is detected with mAbs like Ber-EP4 and MOC-31. The glycoproteins are located on the cell membrane surface and in the cytoplasm of virtually all epithelial cells with the exception of most squamous epithelia, hepatocytes, renal proximal tubular cells, gastric parietal cells and myoepithelial cells. However, focal positivity may be seen in the basal layer of squamous cell epithelium of endoderm (e.g., palatine tonsils) and mesoderm (e.g., uterine cervix). In liver lesions like hepatitis and cirrhosis, the hepatocytes frequently become Ep-CAM positive. Normal mesothelial cells are Ep-CAM negative, but may express focal reaction when undergoing reactive changes. Mesenchymal cells and cells from the neural crest are negative, with the exception of olfactory neurons.